Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+ ATPase in the gastric parietal cells. The S- and R- isomers of omeprazole are protonated and converted in the acidic compartment of the parietal cell forming the active inhibitor, the achiral sulphenamide. By acting specifically on the proton pump, esomeprazole blocks the final step in acid production, thus reducing gastric activity.

Nexium I.V. for Injection is indicated for the short-term treatment (up to 10 days) of Gastroesophageal Reflux Disease (GERD) adult patients with a history of erosive esophagitis, as an alternative to oral therapy in patients when therapy with Nexium (esomeprazole magnesium) Delayed-Release Capsules is not possible or appropriate.

Highest Dev Status	Launched
Therapeutic Area	Gastrointestinal
Potential Indications	Please Login
Identified Action Mechanisms	1
Drug Website	http://www.nexium-us.com
Literature	NCBI