DX-2240, is a human IgG1 which binds to human Tie-1 with high affinity, and stimulates tyrosine phosphorylation of Tie-1 in transfected COS-1 cells and human microvascular endothelial cells. This antibody also binds to Tie-1 on the surface of murine endothelial cells and inhibits (IC50 < 1nM) in vitro tube formation in human umbilical vein endothelial cells and murine lung endothelial cells as well as tube formation in a Matrigel plug implant in vivo model. DX-2240 IgG significantly slowed tumor progression in colorectal, lung and prostate cancer xenograft models in nude mice.

Highest Dev Status	Preclinical
Therapeutic Area	Oncology
Potential Indications	Please Login
Identified Action Mechanisms	4
Literature	NCBI